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A 52-Week Study of Dose Adjusted Subcutaneous Testosterone
Enanthate in Oil Self-Administered Via Disposable Auto-Injector

# A 52-Week Study of Dose Adjusted Subcutaneous Testosterone
Enanthate in Oil Self-Administered via Disposable Auto-Injector

## Abstract
This study investigates the efficacy and safety
of subcutaneously administered testosterone enanthate (TE) in oil form, self-injected using a disposable auto-injector over 52 weeks.
The primary goal was to assess whether dose adjustments could optimize therapeutic outcomes while maintaining patient convenience and adherence.

Data were collected from 100 participants enrolled in a prospective, observational study.
Results indicated that the subcutaneous TE in oil formulation demonstrated consistent efficacy, with serum testosterone levels remaining within the therapeutic range throughout the study period.
Adverse events were mild and comparable to those typically associated with
subcutaneous testosterone administration. This study provides
evidence supporting the safety and practicality of
self-administration of TE in oil via auto-injector for long-term
management of hypogonadism.

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## Authors
John Doe, MD
Jane Smith, PhD

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## Affiliations
Department of Endocrinology, University Hospital, Cityville, Countryname

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## Methods
This prospective, observational study enrolled 100 adult males
(ages 18-65) diagnosed with hypogonadism. Participants received subcutaneous TE in oil via a disposable auto-injector at doses adjusted according to individualized protocols based on blood
testosterone levels and clinical response. Study duration was 52 weeks, with adherence assessed through injection logs and follow-up visits.
Efficacy was measured via serum testosterone,
hemoglobin, and adverse event reporting.

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## Results
Over the course of the study, 95% of participants reported consistent adherence
to their injection regimen. Serum testosterone levels remained within the therapeutic
range (4-12 ng/mL) for all participants, with no significant differences observed between dose adjustment groups.
The incidence of adverse events was low, primarily consisting of
localized pain or erythema at injection sites.

No serious infections or other complications were reported.

Notably, a correlation was observed between dose
and efficacy, with higher doses associated with improved symptoms of hypogonadism (e.g., increased
energy, enhanced libido). However, no evidence of tolerance or rebound hypogonadism was noted during the study period.

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## Discussion
The findings suggest that subcutaneous TE in oil is a safe and
effective alternative for testosterone replacement therapy, particularly for patients who prefer self-administration. The convenience of using a disposable auto-injector may improve
adherence rates compared to traditional vial administration methods.
However, further studies are needed to confirm these
results in larger, diverse populations and to assess long-term outcomes beyond
the 52-week study period.

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## Keywords
Testosterone enanthate, subcutaneous injection, hypogonadism, auto-injector, adherence

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